Memphis Monroe was born in New Orleans, Louisiana and raised in Louisville, Kentucky. At 16 she began working as a waitress at the local Hooters bar and posed for their calendar. When she turned 28 she began nude posing and was signed by Hustler to work for them exclusively after being made the cover girl for the December issue. Her first film was in 2005 and she stayed with Hustler until August 2007.
Memphis, who also has modeled under the name Jamie Lynn, was married in September 2006.